IL-36Ra (human) Matched Pair Detection Set
N° du produit ABIN2745406
Aperçu rapide pour IL-36Ra (human) Matched Pair Detection Set (ABIN2745406)
Antigène
FIL1d
(Interleukin 1 delta (FIL1d))
Application
ELISA
-
-
Méthode de détection
- Colorimetric
-
Type de méthode
- Sandwich ELISA
-
Gamme de detection
- 0.78-50 ng/mL
-
Seuil minimal de détection
- 0.78 ng/mL
-
Type d'échantillon
- Cell Culture Supernatant
-
Specificité
- Detects human IL-36Ra.
-
Réactivité croisée
- Humain
-
Sensibilité
- 0.5 ng/mL
-
Ingrédients
- 1 vial standard protein (1μg) (lyophilized) [STD] 1 vial coating antibody (270μl) [COAT] 1 vial detection antibody (120μl) [DET] 1 vial streptavidin-HRP (10μg) (lyophilized) [STREP]
-
-
-
Indications d'application
- Optimal working dilution should be determined by the investigator.
-
Restrictions
- For Research Use only
-
-
-
Stock
- -20 °C
-
Stockage commentaire
-
Short Term Storage: -20°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C. -
Date de péremption
- 12 months
-
-
- FIL1d (Interleukin 1 delta (FIL1d))
-
Autre désignation
- IL-36Ra
-
Sujet
- IL-36Ra/IL-1F5 is a highly and specific antagonist of the IL-1 receptor-related protein 2-mediated response to IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9). These cytokines bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. Recently mutations that affect the levels and the activity of IL-36Ra have been found in patients with pustular psoriasis, leading to enhanced production of inflammatory cytokines (IL-8 in particular) by keratinocytes.
-
UniProt
- Q9UHA7
Antigène
-
Vous êtes ici:
